Principal Scientist - LC-MS
Pfizer Inc.
Washington – Bothell, NY
Job posting number: #7285765 (Ref:pf-4922065)
Posted: October 5, 2024
Job Description
Job Description
Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
What You Will Achieve
The ADC ADME department is seeking a highly motivated and experienced scientist who will focus on quantitative small molecule mass spectrometry based bioanalytical method development, technical guidance/leadership and cross functional team representation. The ideal candidate will have extensive experience in the following areas: small molecule mass spectrometry method development, sample extraction/preparation from a range of matrices, low volume/high sensitivity assay development, evaluation of bioanalytical data, and troubleshooting/maintaining high-end mass spectrometers. Familiarization with ADCs, PK analyses, in vitro metabolism and stability evaluations are a plus.
How You Will Achieve It
- Develop sample preparation and LC-MS/MS bioanalytical assays to support ADC quantification and characterization of lead research molecules
- Mentor junior colleagues with sample analysis, troubleshooting, and preventative maintenance on mass spectrometers
- Represent team in highly collaborative groups across research, translational sciences and clinical development
Qualifications
- Ph.D., with 3+ years of experience, Master's Degree with 7+ years of experience and a Bachelor's Degree with 9+ years of experience, in bioanalytical quantitative mass spectrometry
- Strong analytical, problem-solving, and decision-making skills
- Strong communication and presentation skills in small groups and for large audiences
Must-Have
- Excellent Method Development and troubleshooting experience with high-end Mass Spectrometers.
- Strong record of scientific achievement and excellent communication skills
- Highly effective written, presentation and verbal communication skills
- Expert knowledge of mass spectrometry and quantitative bioanalysis
Nice-to-Have
- Doctoral Degree (PhD).
- Experience in ADC bioanalysis
- Experience with Agilent LC, Sciex operating systems, and Watson
PHYSICAL/MENTAL REQUIREMENTS
- General lab activities, including moving reagents and instrument maintenance requiring fine motor skills
Work Location Assignment:On Premise with relocation support available.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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