What You Will Achieve

This is an exciting opportunity to join theInternal Medicine Research Unit (IMRU). The strategic focus of the IMRU at Pfizer is to identify novel therapies for preventing or treating chronic cardiovascular, renal, and metabolic diseases. Our goal is to build a world-class research team of dedicated scientists committed to developing a deep mechanistic understanding of the pathways underlying disease pathogenesis.

We are seeking a Postdoctoral Fellow to join the IMRU Integrative Biology team to investigate integrative approaches that would enhance our application of human genetics and single-cell epigenomics to drug discovery. The ideal candidate must be able to independently drive their research project forward and effectively communicate their findings with scientific partners representing diverse disciplines. Knowledge and experience in either human genetics or single-cell analysis is essential, and experience researching common cardiovascular, renal, or metabolic diseases is preferred. The candidate will be expected to present their findings at scientific meetings and publish their research in a peer-reviewed journal.

How You Will Achieve It

Successful candidates will be expected to:

• Design and execute computational analyses to understand the biology underlying disease risk and mechanisms of GWAS loci through integration of genetic and single-cell genomics datasets
• Work closely with colleagues from other disciplines within Pfizer including experts in biology or machine learning
• Presentresearch findings toPfizer colleagues andthe scientific community through publications in peer-reviewed journals andtalks and postersat both internal and external scientific meetings.

Qualifications

Must-Have

• PhD in Computational Biology, Bioinformatics, Human Genetics, or related field with directly relevant experience
• Proven experience with applying standard tools and pipelines for analyzing genetics (GWAS meta-analysis, fine-mapping, colocalization, LD score regression) or large-scale single-cell (Scanpy, snapATAC2, Seurat, Signac) datasets
• Demonstrated proficiency with Python or R and experience working in a Linux/Unix high-performance computing environment
• Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal
• Demonstrated ability to effectively communicate complex genetics and computational biology results to both technical and non-technical audiences
• Willingness to make a minimum 2-year commitment
• No more than 2 years of post-degree experience.

Nice-to-Have

• Experience researching mechanisms of cardiovascular, renal, or metabolic diseases
• Experience applying sequence-based machine learning models to derive insights from genetics or single-cell datasets
• Experience integrating genetics with multi-modal (epigenomics, transcriptomics, proteomics, and metabolomics) datasets

PHYSICAL/MENTAL REQUIREMENTS

Ability to use standard and non-standard statistical and computational software; ability to perform complex data analysis

OTHER JOB DETAILS

Must have work authorization in the US.
Work Location Assignment:Flexible. Flexible colleagues are assigned a Pfizer site within a commutable distance where they work about 2-3 days weekly to connect and innovate with their team face-to-face. However, they also benefit from being able to work offsite regularly when it makes business sense to do so.

The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Research and Development